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07:57
Assessing Whole-Body Lipid-Handling Capacity in Mice
Published on: November 24, 2020
Fasting cholesteryl ester transfer protein concentration is independently associated with the postprandial decrease
Marjan Alssema1, Karim El-Harchaoui, Roger K Schindhelm
1EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands. m.alssema@vumc.nl
Metabolism: Clinical and Experimental
|December 17, 2009
Summary
Higher fasting cholesteryl ester transfer protein (CETP) concentrations are linked to lower high-density lipoprotein cholesterol (HDL-c) after fat-rich meals in postmenopausal women. This finding suggests CETP influences postprandial lipid profiles, impacting cardiovascular health.
Area of Science:
- Lipid Metabolism and Cardiovascular Health
- Endocrinology and Diabetes Research
Background:
- Cholesteryl ester transfer protein (CETP) plays a role in lipoprotein metabolism.
- Postprandial lipid changes, particularly in high-density lipoprotein cholesterol (HDL-c), are crucial for cardiovascular risk assessment.
- Understanding factors influencing postprandial HDL-c is important, especially in postmenopausal women and those with type 2 diabetes mellitus (T2DM).
Purpose of the Study:
- To investigate the association between fasting and postprandial CETP concentrations and postprandial HDL-c changes.
- To examine these associations following consumption of fat-rich versus carbohydrate-rich meals in postmenopausal women.
- To compare findings across women with normal glucose metabolism (NGM), T2DM, and T2DM on statin therapy (T2DM-ST).
Main Methods:
- A study involving 155 postmenopausal women (76 NGM, 41 T2DM, 38 T2DM-ST).
- Participants consumed two consecutive fat-rich or carbohydrate-rich meals on separate occasions.
- Linear regression analysis was used to assess the relationship between CETP concentrations and postprandial HDL-c changes.
Main Results:
- Mean plasma HDL-c concentrations decreased significantly after fat-rich meals across all groups.
- Higher fasting CETP concentrations, but not postprandial CETP, were associated with a larger postprandial decrease in HDL-c after fat-rich meals.
- This association was independent of postprandial triglyceride increases and consistent across NGM, T2DM, and T2DM-ST groups.
Conclusions:
- Elevated fasting CETP concentrations may contribute to a postprandial atherogenic lipoprotein profile in postmenopausal women.
- High fasting CETP levels are linked to reduced HDL-c levels after consuming fat-rich meals.
- This effect appears independent of postprandial triglyceride elevations, highlighting CETP's role in lipid metabolism modulation.
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