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Synthesis and screening of a CaaL peptide library versus FTase reveals a surprising number of substrates
Amanda J Krzysiak1, Animesh V Aditya, James L Hougland
1Department of Medicinal Chemistry and Molecular Pharmacology and Center for Cancer Research, Purdue University, West Lafayette, IN 47907, United States.
Abstract:
Proteins bearing a CaaL sequence are typically geranylgeranylated to enable their proper localization and function. We found that many of the dansyl-GCaaL peptides representing mammalian CaaL proteins can be farnesylated by FTase. This result may have important implications for prenylated protein biology.
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