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Updated: Jun 17, 2026

Exploring the Arginine Methylome by Nuclear Magnetic Resonance Spectroscopy
07:02

Exploring the Arginine Methylome by Nuclear Magnetic Resonance Spectroscopy

Published on: December 16, 2021

Protein arginine methylation in estrogen signaling and estrogen-related cancers

Catherine Teyssier1, Muriel Le Romancer, Stéphanie Sentis

  • 1INSERM U554, Montpellier 34090, France.

Trends in Endocrinology and Metabolism: TEM
|December 17, 2009
PubMed

Insights

Arginine methylation, a post-translational modification, is crucial for estrogen signaling and hormone-dependent cancers. Understanding these modifications offers new insights into cancer development and potential therapeutic targets.

Area of Science:

  • Molecular Biology
  • Cellular Signaling
  • Epigenetics

Background:

  • Estrogen signaling regulates vital cellular functions like proliferation and differentiation.
  • Dysregulation of estrogen pathways contributes to various human diseases.
  • Post-translational modifications (PTMs) significantly influence estrogen signaling.

Purpose of the Study:

  • To review recent findings on arginine methylation of non-histone proteins in estrogen signaling.
  • To explore the role of protein arginine methyltransferases and demethylases.
  • To examine the interplay between arginine methylation and other PTMs in hormone signaling.

Main Methods:

  • Literature review of recent research on protein arginine methylation.
  • Analysis of the function of methylarginine proteins in estrogen action.
  • Investigation of crosstalk between arginine methylation and other PTMs (e.g., phosphorylation, lysine methylation).

Main Results:

  • Arginine methylation is a key PTM influencing estrogen signaling pathways.
  • Protein arginine methyltransferases and demethylases regulate these modifications.
  • Interactions between various PTMs, including arginine methylation, form a regulatory code in hormone signaling.
  • Dysregulation of arginine methylation is implicated in estrogen-dependent cancers, such as breast cancer.

Conclusions:

  • Arginine methylation plays a critical role in estrogen signaling and cellular processes.
  • The interplay of PTMs, particularly arginine methylation, is vital for hormone signaling.
  • Aberrant arginine methylation is linked to the development of estrogen-dependent cancers, highlighting its potential as a therapeutic target.

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