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A newly identified Crimean-Congo hemorrhagic fever virus strain in Turkey

Murat Elevli1, Ayse Ayaz Ozkul, Mahmut Civilibal

  • 1Department of Pediatrics, Haseki Education and Research Hospital, Istanbul, Turkey.

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
|December 17, 2009
PubMed

Insights

Crimean-Congo hemorrhagic fever (CCHF), a tick-borne viral illness, was diagnosed in a child in Istanbul. Phylogenetic analysis identified a new CCHF strain, offering insights into transmission dynamics.

Area of Science:

  • * Virology
  • * Epidemiology
  • * Infectious Diseases

Background:

  • * Crimean-Congo hemorrhagic fever (CCHF) is a severe tick-borne viral disease with a wide geographic distribution, affecting human health across approximately 30 countries.
  • * The extensive range of CCHF makes it a significant public health concern, necessitating ongoing surveillance and research.

Observation:

  • * A 6-year-old boy presented with symptoms including fever, fatigue, and loss of appetite following a tick bite in rural Istanbul.
  • * Clinical examination revealed hyperemia at the tick bite site, and laboratory tests indicated elevated liver enzymes (ALT, AST), LDH, CK, and prolonged coagulation times (PT, aPTT).

Findings:

  • * Diagnostic assays, including anti-CCHF virus IgM ELISA and RT-PCR, confirmed CCHF infection.
  • * Phylogenetic analysis identified the causative agent as a novel AP92-like CCHF strain, designated KMAG-Hu-07-01 (accession number EU057975).

Implications:

  • * This case highlights the presence of CCHF in Istanbul and the potential for novel strain emergence.
  • * The detailed clinical and genetic information from this pediatric case can enhance understanding of CCHF transmission dynamics and inform public health strategies.

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