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Updated: Jun 17, 2026
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Intrafemoral Injection of Human Hematopoietic Stem and Progenitor Cells into Immunocompromised Mice
Published on: December 8, 2023
Allogeneic stem cell transplantation for myelofibrosis with leukemic transformation
Stefan O Ciurea1, Marcos de Lima, Sergio Giralt
1Department of Stem Cell Transplantation and Cellular Therapy, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX, USA.
Summary
Allogeneic stem cell transplantation (ASCT) offers hope for patients with leukemic transformation (LT) from myelofibrosis. This study indicates ASCT can lead to long-term remission in this high-risk group.
Area of Science:
- Hematology
- Oncology
- Stem Cell Transplantation
Background:
- Leukemic transformation (LT) from myelofibrosis is associated with a poor prognosis.
- Current treatment strategies for LT have limited efficacy.
Purpose of the Study:
- To evaluate the effectiveness of allogeneic stem cell transplantation (ASCT) in patients with LT from myelofibrosis.
- To assess long-term outcomes and remission rates following ASCT.
Main Methods:
- Retrospective review of 55 myelofibrosis patients treated with ASCT.
- Identification of 14 patients with LT, 13 of whom received induction chemotherapy.
- Analysis of engraftment, remission rates, relapse, and survival post-ASCT.
Main Results:
- All 14 patients with LT engrafted and achieved remission post-transplant.
- Six patients (49%) achieved long-term survival after a median follow-up of 31 months.
- Four patients experienced relapse after initial remission.
Conclusions:
- ASCT, following induction chemotherapy, may improve long-term remission rates for patients with myelofibrosis and LT.
- Despite limitations of a small cohort, ASCT shows potential as a therapeutic option for this challenging condition.
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