Related Experiment Video
Updated: Jun 17, 2026
A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
Published on: November 13, 2016
Differences in TMS-evoked responses between schizophrenia patients and healthy controls can be observed without a
Nava Levit-Binnun1, Vladimir Litvak, Hillel Pratt
1Department of Physics of Complex Systems, The Weizmann Institute of Science, Rehovot, Israel. navalb@idc.ac.il
Objective:
The combination of transcranial magnetic stimulation (TMS) and electroencephalography (EEG) has been hampered by the large artifact that the TMS generates in the EEG. Using TMS with EEG necessitates a sophisticated artifact-resistant EEG system that can acquire reliable signals in the crucial several tens of milliseconds immediately following the TMS pulse. Here, we demonstrate the use of a novel artifact removal algorithm together with a 24-bit EEG system to achieve similar recordings as those obtained with the dedicated TMS-compatible EEG system.
Methods:
This setup was used to compare TMS-evoked responses between a group of healthy controls and a group of patients with schizophrenia, a condition in which effective neural connectivity is thought to be compromised.
Results:
We observe differences in TMS-evoked responses between the two groups, similar to those recently reported in a study that used a dedicated TMS-compatible EEG system.
Conclusions:
The standard 24-bit EEG system combined with an artifact removal algorithm produces results similar to the dedicated TMS-compatible system.
Significance:
This paves the way for more researchers and clinicians to use TMS-evoked responses for research and diagnosis of a wide spectrum of disorders.
