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High-dose bone morphogenetic protein-induced ectopic abdomen bone growth.

Harel Deutsch¹

¹Rush University Medical Center, 1725 W. Harrison St. #970, Chicago, IL 60612, USA. harel_deutsch@rush.edu

The Spine Journal : Official Journal of the North American Spine Society

|December 17, 2009

Summary

Bone morphogenetic protein (BMP) is common in spinal fusion. A rare complication of BMP use is ectopic bone growth outside the spine, as seen in this case report.

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Area of Science:

Spinal surgery
Biomaterials in orthopedics
Bone regeneration

Background:

Bone morphogenetic protein (BMP) is widely utilized in spinal fusion procedures.
Its use aims to enhance bone formation and promote successful fusion.

Observation:

A 55-year-old male developed weight loss, pain, and a palpable mass post-spinal fusion surgery.
Imaging revealed ectopic bone growth in the retroperitoneal area and pelvis.

Findings:

Surgical exploration confirmed a large sheet of extraspinal ectopic bone growth.
This complication was associated with the use of multiple units of BMP during the initial fusion.

Implications:

This case highlights a rare but significant complication of BMP use in spinal surgery.
Awareness of this potential adverse event is crucial for surgeons utilizing BMP.
Further investigation into risk factors and prevention strategies may be warranted.