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Updated: Jun 17, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
Helpers of the cellular gatekeeper-miRNAs dance in P53 network
Ming Shi1, Dan Liu, Beifen Shen
1Department of Molecular Immunology, Institute of Basic Medical Sciences, Beijing 100850, People's Republic of China.
Abstract:
Recent findings position microRNA (miRNAs) as novel key players in regulating expression of protein-coding genes by interfering with the stability and/or translation of specific target mRNAs and in controlling cell proliferation and differentiation by actively functioning in the p53 tumor suppression network. Accumulating evidence reveal the intimate relationship between p53 and miRNAs. P53 regulates the expression of miRNAs at multiple levels. miRNAs influence the post-transcriptional regulation and activities of p53 by invoking a myriad of mechanisms. These findings are unveiling the unknown mechanisms of the p53-mediated biological effects.
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