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Related Experiment Video

Updated: Jun 17, 2026

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

Podocytes and glomerular function with aging.

Jocelyn Wiggins¹

¹Division of Geriatrics, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109-5676, USA. wiggi@umich.edu

Seminars in Nephrology

|December 17, 2009

Summary

This summary is machine-generated.

Kidney function declines with age, leading to glomerulosclerosis. Calorie restriction may modify this aging pathology, with podocyte cells playing a critical role in kidney aging.

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Area of Science:

Gerontology
Nephrology
Cell Biology

Background:

Kidney function naturally declines with aging.
Age-associated glomerulosclerosis is a common pathology.
Podocytes are crucial cells within the glomerulus.

Purpose of the Study:

To review age-related structural and functional kidney changes.
To discuss the impact of calorie restriction on aging kidney pathology.
To explore the role of podocytes in kidney aging.

Main Methods:

Review of established age-related kidney changes.
Analysis of animal models and human biopsy data on podocyte aging.
Discussion of recent findings on glomerular gene expression.

Main Results:

Aging kidneys exhibit specific structural and functional alterations.
Calorie restriction shows potential in modifying age-related kidney pathology.
Podocyte cells are implicated as key players in the kidney aging process.

Conclusions:

Podocyte biology is central to kidney aging.
Changes in glomerular gene expression may impact kidney disease progression.
Further research into podocyte function could reveal therapeutic targets for age-related kidney diseases.