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Updated: Jun 17, 2026
Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice
Published on: February 18, 2016
Individual differences in activity predict locomotor activity and conditioned place preference to amphetamine in both
Iva Z Mathews1, Mark D Morrissey, Cheryl M McCormick
1Department of Psychology and Neuroscience Program, Brock University, St. Catharines, ON, Canada.
Abstract:
Individual and developmental differences in novelty seeking have been implicated in differential sensitivity to psychostimulants in rodents, but findings are mixed. The extent to which age differences in activity in a novel arena depended on test duration was examined by comparing adolescent and adult rats after 5 and after 60 min of testing (session 1). Rats were tested again after amphetamine or saline administration 24h later (session 2) to examine whether activity in a novel arena predicts sensitivity to locomotor-activating effects of amphetamine. Data from two experiments were used to examine consistency of the findings. Only activity in 60 min sessions produced a consistent age difference (adolescent
