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Antiviral flavonoids from Mosla scabra.
Qiaofeng Wu1, Chenhuan Yu, Yunliang Yan
1College of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, China. wqfyjm@sina.com
Fitoterapia
|December 17, 2009
Summary
Mosla scabra extracts show potent anti-influenza virus activity. Certain isolated compounds demonstrated significant efficacy, suggesting potential as a less toxic influenza treatment.
Area of Science:
- Phytochemistry
- Virology
- Pharmacology
Background:
- Influenza viruses pose a significant global health threat, necessitating the development of novel antiviral agents.
- Natural products are a promising source for discovering new therapeutic compounds with antiviral properties.
Purpose of the Study:
- To investigate the antiviral activity of Mosla scabra extracts and isolated compounds against influenza viruses.
- To identify the specific compounds responsible for the observed anti-influenza effects and assess their therapeutic potential.
Main Methods:
- Preparation of ethanolic extract and ethyl acetate fraction (EFMS) from Mosla scabra.
- Isolation and structural elucidation of compounds from EFMS using spectral analysis.
- Evaluation of anti-influenza virus activities of EFMS and isolated compounds.
Main Results:
- EFMS exhibited potential inhibition against influenza viruses.
- Five compounds were isolated: ursolic acid (1), 5-hydroxy-6,7-dimethoxyflavone (2), 5-hydroxy-7,8-dimethoxyflavone (3), apigenin (4), and acacetin (5).
- Compounds 2, 3, 4, and 5 demonstrated significant anti-influenza virus activities, with EFMS showing comparable efficacy to ribavirin but with lower toxicity.
Conclusions:
- Mosla scabra contains compounds with significant anti-influenza virus activity.
- Compounds 5-hydroxy-6,7-dimethoxyflavone, 5-hydroxy-7,8-dimethoxyflavone, apigenin, and acacetin are key contributors to the antiviral effect.
- EFMS represents a potential candidate for further development as a less toxic therapeutic agent for influenza treatment.
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