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Chiral silica-based monoliths in chromatography and capillary electrochromatography
1Institute of Organic Chemistry, University of Tübingen, 72076 Tübingen, Germany. dorothee.wistuba@orgchem.uni-tuebingen.de
Journal of Chromatography. A
|December 17, 2009
Summary
Chiral-modified silica monoliths are effective for enantioselective separations using high performance liquid chromatography (HPLC) and capillary electrochromatography (CEC). This review covers their development and application in nano-HPLC and CEC.
Area of Science:
- Analytical Chemistry
- Separation Science
- Chromatography
Background:
- Chiral-modified silica-based monoliths are established stationary phases for HPLC and CEC.
- These monoliths can be fabricated in situ for nano-HPLC/CEC or in molds for conventional HPLC.
Purpose of the Study:
- To review the chiral modification of silica monoliths.
- To summarize recent developments in enantioselective separations using nano-HPLC and CEC.
Main Methods:
- Fabrication of silica-based monoliths in capillaries (in situ) or molds.
- Application of these monoliths as stationary phases in HPLC and CEC.
Main Results:
- Silica monoliths provide effective chiral stationary phases.
- Successful enantioselective separations achieved via nano-HPLC and CEC.
Conclusions:
- Chiral-modified silica monoliths are versatile for enantioselective separations.
- Advancements in nano-HPLC and CEC utilizing these phases are significant.
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