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Updated: Jun 17, 2026
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
Immunogenicity of a psoralen-inactivated dengue virus type 1 vaccine candidate in mice
Ryan C Maves1, Roger M Castillo Oré, Kevin R Porter
1U.S. Naval Medical Research Center Detachment, Lima, Peru. Ryan.Maves@med.navy.mil
Abstract:
We evaluated a novel psoralen-inactivated dengue virus type 1 (DENV-1) vaccine candidate in Mus musculus mice. Mice received intradermal alum or 5 to 10 ng of psoralen-inactivated virus. Anti-DENV-1 neutralizing antibody was detectable in 10/11 mice receiving a 10-ng dose at 90 days. Psoralen-inactivated DENV-1 is immunogenic in mice.
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