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Related Experiment Video

Updated: Jun 17, 2026

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

Newborn screening for non-sickling hemoglobinopathies.

Carolyn C Hoppe1

  • 1Children's Hospital & Research Center Oakland, Oakland, CA 94609, USA. choppe@mail.cho.org

Hematology. American Society of Hematology. Education Program
|December 17, 2009
PubMed
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Newborn screening for non-sickling hemoglobinopathies is crucial due to changing US demographics. Expanding screening beyond sickle cell disease can improve early detection and care for these increasingly common genetic blood disorders.

Area of Science:

  • Genetics
  • Hematology
  • Public Health

Background:

  • Hemoglobinopathies are genetic blood disorders caused by mutations in alpha- and beta-globin genes.
  • Non-sickling hemoglobinopathies are prevalent in Mediterranean, Asian, and Southeast Asian populations.
  • The US population is diversifying, leading to a shifting geographic distribution of these disorders.

Purpose of the Study:

  • To review the increasing prevalence of non-sickling hemoglobinopathies in the US.
  • To highlight the need for expanding newborn screening programs.
  • To emphasize the importance of early detection and care for affected infants.

Main Methods:

  • Review of existing literature on hemoglobinopathies and newborn screening.
  • Analysis of demographic trends and their impact on disease prevalence.

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Last Updated: Jun 17, 2026

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

Magnetic Levitation Coupled with Portable Imaging and Analysis for Disease Diagnostics
07:42

Magnetic Levitation Coupled with Portable Imaging and Analysis for Disease Diagnostics

Published on: February 19, 2017

  • Examination of current newborn screening policies and their limitations.

    • Main Results:

    • The prevalence of non-sickling hemoglobinopathies is rising in the US due to population shifts.
    • Current newborn screening for these disorders is inconsistent and often limited.
    • Early intervention and specialized care significantly improve patient outcomes.

    Conclusions:

    • Expanding newborn screening for hemoglobinopathies beyond sickle cell disease is warranted.
    • Public health programs must adapt to the changing epidemiology of these disorders.
    • Timely diagnosis and comprehensive care are essential for managing hemoglobinopathies.