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Factor XI deficiency--resolving the enigma?

Paula H B Bolton-Maggs1

  • 1Department of Clinical Haematology, Manchester Royal Infirmary, Manchester, United Kingdom. paula.bolton-maggs@manchester.ac.uk

Hematology. American Society of Hematology. Education Program
|December 17, 2009
PubMed

The management of factor XI deficiency is not straightforward for three reasons: firstly, the role of this factor in the coagulation pathway is not clearly understood; secondly, the bleeding tendency, although mild, is unpredictable and does not clearly relate to the factor XI level; and thirdly, all treatment products, although available, have some potentially serious side effects. These factors (or enigmas) contribute to the variable management of patients with this coagulation factor deficiency, but recent research is helping to clarify some of these areas.

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