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Updated: Jun 17, 2026
10:04
Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
Published on: May 1, 2015
Novel therapies for relapsed myeloma
1Hematology and Oncology, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA. stewart.keith@mayo.edu
Hematology. American Society of Hematology. Education Program
|December 17, 2009
Summary
Individualized treatment for myeloma relapse considers prior therapies and patient factors. Novel agents like carfilzomib and pomalidomide offer new options for patients with relapsed multiple myeloma.
Area of Science:
- Oncology
- Hematology
- Pharmacology
Background:
- Multiple myeloma relapse necessitates tailored treatment strategies.
- Prior therapy effectiveness, toxicity, and patient-specific factors guide treatment decisions.
- Combination therapies generally yield higher response rates and improved progression-free survival.
Purpose of the Study:
- To review novel agents for relapsed multiple myeloma.
- To discuss the pros and cons of preclinical testing for new myeloma drugs.
- To focus on carfilzomib and pomalidomide as examples of novel agents with single-agent activity.
Main Methods:
- Review of current literature on myeloma relapse treatment.
- Analysis of novel drug classes in clinical trials for multiple myeloma.
- Focus on preclinical and clinical data for carfilzomib and pomalidomide.
Main Results:
- Individualized treatment plans are crucial for relapsed myeloma.
- Novel agents are expanding therapeutic options for relapsed multiple myeloma.
- Carfilzomib (proteasome inhibitor) and pomalidomide (immunomodulatory drug) show single-agent activity.
Conclusions:
- Treatment for relapsed multiple myeloma should be individualized.
- Novel agents, including carfilzomib and pomalidomide, represent promising advancements.
- Further research is needed to determine optimal sequencing versus combination therapy for overall survival.
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