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Related Experiment Videos

Plasma tocopherol concentrations in response to supplemental vitamin E.

N V Dimitrov1, C Meyer, D Gilliland

  • 1Department of Medicine, College of Human Medicine, Michigan State University, East Lansing 48824.

The American Journal of Clinical Nutrition
|March 1, 1991
PubMed
Summary

This study shows that vitamin E (dl-alpha-tocopherol) supplements increase blood levels, reaching peak concentration within 24 hours. Dietary fat intake significantly impacts vitamin E absorption and blood levels.

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Area of Science:

  • Nutritional Science
  • Biochemistry

Background:

  • Vitamin E, specifically dl-alpha-tocopherol, is a crucial fat-soluble antioxidant.
  • Understanding its pharmacokinetics is essential for effective supplementation and health management.

Purpose of the Study:

  • To investigate the plasma kinetics of dl-alpha-tocopherol following various single and chronic doses in healthy adults.
  • To assess the impact of dietary fat on dl-alpha-tocopherol absorption and plasma concentrations.

Main Methods:

  • Healthy volunteers received single or daily doses of dl-alpha-tocopherol (440, 880, or 1320 mg) for 28 days.
  • Plasma alpha-tocopherol levels were monitored over time.
  • The influence of high-fat versus low-fat diets was evaluated.

Main Results:

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  • Single doses elevated plasma alpha-tocopherol, peaking at 12-24 hours.
  • Chronic supplementation reached a steady state by days 4-5.
  • Plasma levels returned to baseline within 12-20 days after cessation.
  • Higher plasma concentrations were observed with high-fat diets.

Conclusions:

  • Plasma kinetics of dl-alpha-tocopherol are consistent across tested doses (440-1320 mg) in healthy individuals.
  • Dietary fat significantly enhances the absorption and plasma elevation of dl-alpha-tocopherol.
  • These findings inform optimal vitamin E supplementation strategies.