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Related Concept Videos

Global Regulatory Systems01:28

Global Regulatory Systems

Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
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Cis-regulatory Sequences02:02

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Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
Cis-regulatory Sequences02:02

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Reporter Genes02:11

Reporter Genes

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Master Transcription Regulators02:23

Master Transcription Regulators

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Related Experiment Video

Updated: Jun 17, 2026

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
10:44

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

Published on: December 7, 2021

Gene-centered regulatory networks.

H Efsun Arda1, Albertha J M Walhout

  • 1Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605, USA. marian.walhout@umassmed.edu

Briefings in Functional Genomics
|December 17, 2009
PubMed
Summary
This summary is machine-generated.

This study explores gene regulatory networks (GRNs) in multicellular organisms. We used gene-centered methods to understand the fundamental principles of gene regulation in complex animal systems.

More Related Videos

Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes
07:55

Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes

Published on: May 31, 2011

Related Experiment Videos

Last Updated: Jun 17, 2026

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
10:44

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

Published on: December 7, 2021

Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes
07:55

Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes

Published on: May 31, 2011

Area of Science:

  • Molecular Biology
  • Systems Biology
  • Genomics

Background:

  • Differential gene expression is crucial for multicellular organism development and physiology.
  • Gene regulatory network (GRN) models represent gene interactions at a systems level.
  • Mapping GRNs involves diverse experimental and computational techniques.

Purpose of the Study:

  • To discuss gene-centered approaches for characterizing GRNs.
  • To provide insights into the global design principles of gene regulation.
  • To analyze gene regulation in complex metazoan systems.

Main Methods:

  • Employed gene-centered methodologies.
  • Utilized computational and experimental approaches for GRN mapping.
  • Focused on analyzing interactions within metazoan systems.

Main Results:

  • Characterized GRNs using gene-centered strategies.
  • Gained insights into the design principles governing gene regulation.
  • Identified key regulatory interactions in complex organisms.

Conclusions:

  • Gene-centered approaches effectively characterize GRNs.
  • Understanding GRNs reveals global design principles of gene regulation.
  • This work advances the study of gene regulation in metazoan systems.