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Related Experiment Video

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An Optogenetic Method to Control and Analyze Gene Expression Patterns in Cell-to-cell Interactions

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Published on: March 22, 2018

Controlling biological networks by time-delayed signals.

Gábor Orosz¹, Jeff Moehlis, Richard M Murray

¹Department of Mechanical Engineering, University of California, Santa Barbara, CA 93106, USA. gabor@engineering.ucsb.edu

Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences

|December 17, 2009

Summary

This study shows that time-delayed feedback can control biological networks like transcriptional and neural systems. This method offers a tunable and biocompatible tool for engineering biological system behavior.

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Area of Science:

Systems Biology
Control Theory
Bioengineering

Background:

Biological networks, including transcriptional and neural systems, exhibit complex dynamics.
Precise control over these biological systems is crucial for understanding and engineering their functions.

Purpose of the Study:

To investigate the application of time-delayed feedback for regulating biological network behavior.
To demonstrate the construction of robust and tunable controllers for biological systems.

Main Methods:

Utilizing time-delayed feedback principles.
Applying these principles to specific examples of transcriptional regulatory networks.
Demonstrating control in neural network models.

Main Results:

Robust and tunable controllers were successfully constructed.
Model-engineered inputs were provided to biological systems.
The efficacy of time delay modulation as a control tool was shown.

Conclusions:

Time-delayed feedback is an effective strategy for controlling biological networks.
This approach offers a biocompatible and tunable method for system regulation.
Modulating time delays presents a promising avenue for bioengineering applications.