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Related Experiment Videos

Potential cost-avoidance with oral extended-release morphine sulfate tablets versus morphine sulfate solution.

B R Goughnour1, W W Arkinstall

  • 1Department of Pharmacy Services, Kelowna General Hospital, British Columbia, Canada.

American Journal of Hospital Pharmacy
|January 1, 1991
PubMed
Summary

Extended-release morphine sulfate tablets offer a cost-effective alternative to morphine sulfate solution. Despite higher acquisition costs, the total daily therapy expenses are significantly lower for the extended-release formulation.

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Area of Science:

  • Pharmacoeconomics
  • Pain Management
  • Formulation Science

Background:

  • Morphine sulfate is a common analgesic.
  • Extended-release (ER) formulations aim to improve patient convenience and potentially reduce costs.
  • Comparing the economic and logistical aspects of different morphine sulfate formulations is crucial for healthcare providers.

Purpose of the Study:

  • To compare the acquisition, preparation, and administration costs of morphine sulfate extended-release tablets versus morphine sulfate solution.
  • To evaluate the time efficiency of administering these two morphine sulfate formulations in an acute-care setting.

Main Methods:

  • Pharmacists at a community hospital timed the preparation and administration of single doses of morphine sulfate ER tablets (60 mg) and morphine sulfate solution (5 mg/mL).

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  • Labor costs were calculated using mean task times and median wage scales.
  • Acquisition and ancillary supply costs were included to determine overall therapy costs.

    • Main Results:

    • Total single-dose administration time did not differ significantly between formulations.
    • For a total daily dose of 120 mg, administering morphine sulfate ER tablets twice daily required 8.90 minutes, compared to 23.44 minutes for the solution administered six times daily.
    • Despite higher initial acquisition costs, the total daily therapy cost for ER tablets was less than half that of the solution.

    Conclusions:

    • Morphine sulfate extended-release tablets are a more cost-effective option for daily pain management compared to the solution, primarily due to reduced administration time.
    • The clinical advantages and cost-avoidance potential make ER morphine sulfate tablets an attractive therapeutic choice.