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Net effect of an acute phase response--partial alleviation with probiotic supplementation
Z Jiang1, G Schatzmayr, M Mohnl
1Department of Animal Sciences, Purdue University, West Lafayette, IN 47906, USA
Poultry Science
|December 17, 2009
Summary
Dietary probiotics partially mitigated growth reduction in broiler chicks experiencing the acute phase response (APR) induced by lipopolysaccharide (LPS). Probiotic supplementation improved feed intake recovery, showing a trend toward better body weight gain despite LPS-induced inflammation.
Area of Science:
- Animal Nutrition
- Immunology
- Poultry Science
Background:
- The acute phase response (APR), triggered by inflammation, leads to reduced growth and appetite in broiler chicks.
- Lipopolysaccharide (LPS) is a common inducer of APR, mimicking bacterial infections and causing significant physiological stress.
- Dietary interventions, such as probiotics, are explored to counteract the negative effects of APR on poultry health and productivity.
Purpose of the Study:
- To investigate the efficacy of a multispecies probiotic (PoultryStar) in alleviating growth suppression and anorexia caused by LPS-induced APR in broiler chicks.
- To determine if probiotic supplementation can mitigate the metabolic disturbances associated with the acute phase response.
Main Methods:
- A 1-week growth experiment involving male broiler chicks from 14 to 21 days of age.
- Four treatment groups: control, LPS-challenged, pair-fed to LPS-challenged, and probiotic-supplemented then LPS-challenged.
- LPS (Escherichia coli O55:B5) was administered intraperitoneally four times to induce APR; probiotic supplementation was administered via feed.
Main Results:
- LPS challenge significantly depressed body weight gain by 22% and reduced feed intake.
- Probiotic supplementation recovered 17% of the growth depression compared to the LPS-challenged group (P = 0.068), with earlier feed intake recovery.
- Probiotic supplementation did not alleviate the reduction in net energy or protein accretion caused by LPS.
Conclusions:
- Acute phase response induced by LPS administration diverts nutrients from tissue accretion.
- Probiotic supplementation lessened the anorexic effects of LPS, showing a trend toward improved body weight gain.
- While probiotics aid in feed intake recovery, they do not fully counteract the metabolic nutrient partitioning changes during LPS-induced APR.
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