Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Asthma III: Clinical Manifestations

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...

Asthma I: Introduction

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

Asthma-I: Introduction

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

Asthma-III: Symptoms and Complications

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma

Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Science, medicine and ethics during COVID-19 pandemic.

Acta paediatrica (Oslo, Norway : 1992)·2021

Same author

Return to School for Children With Tracheostomy or Requiring Noninvasive Ventilation Lessons From the First Lockdown in the United Kingdom.

Chest·2021

Same author

Proposal of 0.5 mg of protein/100 g of processed food as threshold for voluntary declaration of food allergen traces in processed food-A first step in an initiative to better inform patients and avoid fatal allergic reactions: A GA²LEN position paper.

Allergy·2021

Same author

E-Cigarettes as a Growing Threat for Children and Adolescents: Position Statement From the European Academy of Paediatrics.

Frontiers in pediatrics·2021

Same author

COVID-19 and delivery of difficult asthma services.

Archives of disease in childhood·2021

Same author

Electronic reminders and rewards to improve adherence to inhaled asthma treatment in adolescents: a non-randomised feasibility study in tertiary care.

BMJ open·2021

Search research articles

Related Experiment Video

Updated: Jun 17, 2026

Methodology for Sputum Induction and Laboratory Processing

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

Phenotypic differences between pediatric and adult asthma.

Andrew Bush¹, Andrew Menzies-Gow

¹Department of Paediatric Respiratory Medicine, Imperial School of Medicine at National Heart and Lung Institute, London, United Kingdom. a.bush@rbh.nthames.nhs.uk

Proceedings of the American Thoracic Society

|December 17, 2009

Summary

This summary is machine-generated.

Asthma phenotypes vary by age, with early childhood wheezing poorly understood. Understanding early life events is crucial for comprehending multifaceted asthma phenotypes across decades.

More Related Videos

Murine Model of Allergen Induced Asthma

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Related Experiment Videos

Last Updated: Jun 17, 2026

Methodology for Sputum Induction and Laboratory Processing

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

Murine Model of Allergen Induced Asthma

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Area of Science:

Pulmonology
Immunology
Pediatrics

Background:

Asthma phenotyping aims to elucidate disease mechanisms and personalize management strategies.
Phenotypic presentations of asthma exhibit significant age-related variations, particularly in early childhood.
Current phenotyping methods often overlook temporal changes and distal airway involvement.

Purpose of the Study:

To review the age-related variations in asthma phenotypes.
To highlight the limited understanding of early-life wheezing phenotypes and their long-term implications.
To emphasize the need for longitudinal data in characterizing asthma phenotypes.

Main Methods:

Literature review and critical analysis of existing asthma phenotyping studies.
Examination of age-specific asthma phenotypes from infancy through adulthood.
Discussion of limitations in current phenotyping approaches, including cellularity measures.

Main Results:

Preschool wheeze can be categorized into episodic viral or multiple-trigger types for treatment planning.
Severe asthma in children differs from adults, with distinct atopic and gender profiles.
Potential phenotypes include exacerbations driven by airway eosinophilia and adult-onset asthma with progressive lung function decline, possibly originating in childhood.

Conclusions:

Asthma phenotypes are complex and evolve over a lifetime, with early childhood events significantly influencing later disease trajectories.
Longitudinal studies are essential to determine phenotype stability and long-term prognoses.
A comprehensive understanding of asthma requires integrating early life history with long-term outcomes.