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PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke
Published on: June 14, 2018
Radioisotopic imaging of neuroinflammation
Alexandra Winkeler1, Raphaël Boisgard, Abraham Martin
1CEA, I(2)BM, Service Hospitalier Frédéric Joliot, LIME, INSERM U803, 91400 Orsay, France.
Abstract:
Inflammatory responses are closely associated with many neurologic disorders and influence their outcome. In vivo imaging can document events accompanying neuroinflammation, such as changes in blood flow, vascular permeability, tightness of the blood-to-brain barrier, local metabolic activity, and expression of specific molecular targets. Here, we briefly review current methods for imaging neuroinflammation, with special emphasis on nuclear imaging techniques.
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