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Updated: Jun 17, 2026

Long-Term Continuous Measurement of Renal Blood Flow in Conscious Rats
Published on: February 8, 2022
Evaluation of the hemodynamic impact of continuous renal replacement therapy in healthy dogs
Takako Shimokawa Miyama1, Kazuhito Itamoto, Chihiro Yoshioka
1Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University.
Abstract:
We performed continuous renal replacement therapy (CRRT) on clinically healthy dogs to evaluate the effects of CRRT on hemodynamics. Heart rate, arterial blood pressure, and central venous pressure of the dogs (n=6) were recorded during the procedure, which was performed under general anesthesia. Throughout the CRRT, heart rate and arterial blood pressure were stable. Central venous pressure increased after CRRT termination but returned to the basal level within 30 min. In this study, hemodynamic alterations, including hypotension, hypertension, and arrhythmias, were not observed during CRRT. These observations suggest that the CRRT protocol used in the present study can be safely applied to clinical cases with acute renal failure.
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