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Chronic Pancreatitis I: Introduction

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...

Chronic Pancreatitis I: Introduction

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...

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Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...

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Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis

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Chronic progressive polyarthritis in a female cat.

Eiji Oohashi¹, Kazutaka Yamada, Mirai Oohashi

¹Akashiya Animal Hospital, Hokkaido. tino-mero-coro@netbeet.ne.jp

The Journal of Veterinary Medical Science

|December 17, 2009

Summary

This study reports the first case of feline chronic progressive polyarthritis in a genetically female cat. The condition, previously only seen in males, improved with cyclosporine treatment.

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Area of Science:

Veterinary Medicine
Immunology
Genetics

Background:

Feline chronic progressive polyarthritis (FCPP) is a rare immune-mediated joint disease.
FCPP has historically been documented exclusively in male felines.

Observation:

A one-year-old female cat presented with anorexia, lassitude, lameness, joint swelling, pain, stiffness, crepitus, regional lymphadenopathy, and fever.
Diagnostic workup included imaging, antinuclear antibody testing, synovial fluid analysis, and urinalysis, confirming erosive proliferative periosteal polyarthritis.
The cat tested positive for feline leukemia virus antigen and feline immunodeficiency virus antibody.

Findings:

Genetic analysis using the sex-determining region on the Y chromosome gene confirmed the cat was genetically female, challenging previous observations.
Cyclosporine treatment led to rapid and sustained improvement in the cat's clinical condition and mobility for at least 8 months.

Implications:

This case expands the known clinical spectrum of feline chronic progressive polyarthritis to include genetically female cats.
The findings suggest that FCPP may occur in both sexes, necessitating broader diagnostic considerations.
Successful cyclosporine treatment highlights its potential efficacy in managing FCPP, regardless of genetic sex.