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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

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Related Experiment Video

Updated: Jun 17, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

[Malignant lymphoma].

Rumiko Okamoto1

  • 1Dept. of Chemotherapy, Tokyo Metropolitan Cancer and Infectious Disease Center Komagome Hospital, Tokyo, Japan.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|December 17, 2009
PubMed
Summary

18-Fluoro-deoxyglucose positron emission tomography (FDG-PET) is valuable for managing lymphoma patients, aiding in staging and monitoring. New guidelines incorporating FDG-PET aim to standardize response assessment and improve patient outcomes.

Area of Science:

  • Nuclear Medicine
  • Oncology
  • Radiology

Background:

  • 18-Fluoro-deoxyglucose positron emission tomography (FDG-PET) is increasingly utilized in malignant lymphoma management.
  • FDG-PET is assessed for pretreatment staging, restaging, therapy monitoring, and posttherapy surveillance.
  • Conventional staging methods like CT scans and 67gallium scintigraphy are being complemented by FDG-PET.

Purpose of the Study:

  • To evaluate the role of FDG-PET in lymphoma management.
  • To highlight FDG-PET's potential in early-stage disease and radiation therapy planning.
  • To introduce revised response criteria incorporating FDG-PET for standardized lymphoma assessment.

Main Methods:

  • Review of FDG-PET applications in lymphoma staging and monitoring.

Related Experiment Videos

Last Updated: Jun 17, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

  • Analysis of FDG-PET's limitations, including technical challenges and variable uptake.
  • Incorporation of FDG-PET into new response assessment guidelines (Revised Response Criteria for Malignant Lymphoma).

    • Main Results:

    • FDG-PET provides complementary information to conventional staging methods.
    • FDG-PET has limitations such as false-negative and false-positive results and variable avidity across lymphoma subtypes.
    • New guidelines integrating FDG-PET, IHC, and flow cytometry aim to reduce study variability.

    Conclusions:

    • Standardized FDG-PET definitions and criteria are expected to improve lymphoma patient outcomes.
    • FDG-PET is a promising biomarker with the potential to transform lymphoma drug development.
    • Revised response criteria aim to enhance consistency and reliability in lymphoma assessment.