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Immunological persistence in 4-6 and 7-9 year olds previously vaccinated in infancy with hexavalent DTPa-HBV-IPV/Hib

Michael Zinke1, Johann Disselhoff,

  • 1Tengstedter Landstr, Hamburg, Germany.

Human Vaccines
|December 17, 2009
PubMed

Insights

The hexavalent DTPa-HBV-IPV/Hib vaccine provides long-lasting immunity against most childhood diseases up to age 9. However, pertussis immunity wanes, supporting the need for a booster dose in young children.

Area of Science:

  • Pediatric Vaccinology
  • Immunology
  • Public Health

Background:

  • The DTPa-HBV-IPV/Hib vaccine is the sole licensed hexavalent option for infant immunization.
  • It offers simultaneous protection against six critical childhood diseases.

Purpose of the Study:

  • To assess the persistence of immune response after four doses of the hexavalent vaccine.
  • To evaluate antibody levels in children aged 4-6 and 7-9 years.

Main Methods:

  • Serological follow-up of 403 children vaccinated with DTPa-HBV-IPV/Hib.
  • Analysis of antibody persistence at ages 4-6 and 7-9 years post-vaccination.

Main Results:

  • High seroprotective antibody levels persisted for diphtheria, Hib, and poliovirus up to age 9.
  • Antibody levels for Hepatitis B and tetanus remained protective in a majority of subjects.
  • Anti-pertussis toxin antibodies were detectable in less than 40% of subjects by age 9.

Conclusions:

  • The DTPa-HBV-IPV/Hib vaccine induces durable immunity against most antigens.
  • Declining pertussis immunity highlights the importance of booster doses for sustained protection.
Abstract

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