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The association between alcohol consumption and prevalent cardiovascular diseases among HIV-infected and

Matthew S Freiberg1, Kathleen A McGinnis, Kevin Kraemer

  • 1Division of General Internal Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. freibergms@upmc.edu

Journal of Acquired Immune Deficiency Syndromes (1999)
|December 17, 2009
PubMed

Insights

Hazardous alcohol consumption and alcohol abuse are linked to increased cardiovascular disease (CVD) risk in HIV-infected veterans. This highlights the importance of addressing substance use in managing HIV and CVD.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Addiction Medicine

Background:

  • Cardiovascular disease (CVD) is a leading cause of mortality in HIV-infected individuals.
  • Alcohol consumption is a known risk factor for CVD in the general population.
  • The specific impact of alcohol consumption on CVD risk among HIV-infected veterans requires further investigation.

Purpose of the Study:

  • To investigate the association between alcohol consumption patterns and the prevalence of cardiovascular disease (CVD) among HIV-infected veterans.
  • To compare these associations with those observed in HIV-uninfected veterans.
  • To identify specific alcohol consumption thresholds associated with increased CVD risk in this population.

Main Methods:

  • Cross-sectional analysis of data from 4743 men in the Veterans Aging Cohort Study.
  • Participants included both HIV-infected (51%) and HIV-uninfected veterans.
  • Logistic regression was used to estimate odds ratios (OR) for prevalent CVD based on alcohol consumption levels.

Main Results:

  • Hazardous drinking (OR = 1.43) and alcohol abuse/dependence (OR = 1.55) were significantly associated with higher CVD prevalence in HIV-infected men.
  • Past drinking was associated with higher CVD prevalence in HIV-uninfected men (OR = 1.30).
  • Traditional CVD risk factors and kidney disease were independently associated with CVD in both groups.

Conclusions:

  • Hazardous drinking and alcohol abuse/dependence are independently associated with a higher prevalence of CVD in HIV-infected men.
  • These associations persist even after adjusting for traditional CVD risk factors, antiretroviral therapy, and CD4 count.
  • Findings underscore the critical role of alcohol consumption in CVD risk stratification and management for HIV-infected veterans.
Abstract

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