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Hyperammonemic encephalopathy: a rare presentation of fibrolamellar hepatocellular carcinoma
Saurabh Sethi1, Nishant Tageja, Jatinder Singh
1Department of Internal Medicine, Wayne State University/Detroit Medical Center, Detroit, Michigan, USA.
Abstract:
Fibrolamellar carcinoma (FLC) is a rare malignant hepatocellular tumor of unknown etiology, arising almost exclusively from noninfected, noncirrhotic liver of young adults. FLC has traditionally been considered to have better survival than hepatocellular carcinoma; however, this notion might be highly erroneous. Patients with metastatic disease at presentation have a dismal prognosis with 5-year survival of only 15%. We describe a case of highly aggressive metastatic FLC that presented as hyperammonemic encephalopathy, which has never been previously reported in the literature.
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