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Related Experiment Video

Updated: Jun 17, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

Factor V Leiden: a case study and review.

Kimberlee B Slusher¹

¹The Jewish Hospital, Blood and Marrow Transplant Unit, Cincinnati, Ohio, USA. Kimkelly65@yahoo.com

Dimensions of Critical Care Nursing : DCCN

|December 17, 2009

Summary

This summary is machine-generated.

Factor V Leiden is a common inherited blood clotting disorder that increases the risk of deep vein thrombosis and venous thromboembolism. Understanding this mutation is crucial for healthcare professionals to manage patient care effectively.

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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

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Published on: September 9, 2012

Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice

Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice

Published on: September 30, 2021

Area of Science:

Hematology
Genetics
Internal Medicine

Background:

Venous thromboembolism (VTE) is a significant cause of morbidity and mortality, with inherited thrombophilias being a major predisposing factor.
Factor V Leiden is the most prevalent inherited thrombophilia, affecting blood clotting mechanisms.
The mutation confers resistance to activated protein C, impairing the natural anticoagulation system.

Observation:

Factor V Leiden thrombophilia is an inherited mutation impacting blood clotting.
This mutation leads to resistance to activated protein C, disrupting natural anticoagulation.
Patients with Factor V Leiden have a predisposition to recurrent deep vein thrombosis (DVT).

Findings:

The Factor V Leiden mutation is the most common inherited disorder predisposing to VTE.
It causes a defect in the natural anticoagulation system by conferring resistance to activated protein C.
Combined with other risk factors, it significantly increases the risk of VTE and associated morbidity.

Implications:

Effective management of Factor V Leiden requires understanding its pathophysiology and risk factors.
Accurate diagnosis and testing are essential for identifying at-risk individuals.
Nursing professionals need comprehensive knowledge of Factor V Leiden for optimal patient care and prevention of VTE complications.