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Updated: Jun 17, 2026
Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation
Published on: January 14, 2014
The potential of resveratrol against human gliomas
Nicoletta Gagliano1, Giancarlo Aldini, Graziano Colombo
1Department of Human Morphology and Biomedical Sciences 'Cittá Studi, Universitá di Milano, School of Medicine, Extracellular Matrix Laboratory, Via Fratelli Cervi 93, 20090 Segrate, Milan, Italy. nicoletta.gagliano@unimi.it
Abstract:
There is growing interest in dietary phytochemicals as potential cancer chemopreventive agents. Resveratrol (3,4',5-trihydroxy-trans-stilbene), a naturally occurring phytoalexin that is present in grapes, red wine, berries and peanuts, has been studied extensively for its ability to interfere with multistage carcinogenesis. Resveratrol is known to have antioxidant, anti-inflammatory and antiproliferative effects on a variety of cancer cells in vitro and in various animal models. However, the effect(s) of resveratrol in vivo on humans are still controversial. This study discusses current knowledge with regard to the effects of resveratrol in relation to its potential as a chemopreventive and/or chemotherapeutic molecule against human gliomas.
