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Updated: Jun 17, 2026

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
Published on: October 17, 2025
Neuroendocrine pathways altered in autism. Special role of reelin
Silvia Kelemenova1, Daniela Ostatnikova
1Institute of Physiology, Faculty of Medicine, Comenius University, Bratislava, Slovakia. skelemenova@gmail.com
Abstract:
Autism is the most genetically influenced neuropsychiatric disorder with heritability of approximately 90%. Since genetic factors seem to play a crucial role in autism etiology, enormous attention is focused on genetic analyses of the disorder. Reelin, one of the autism candidates, is necessary in regulation of neuronal migration during brain development and also in maintaining synaptic plasticity during postnatal life period. Reduced reelin levels were observed in sera and brain cortices of autistic patients. In this review, abnormalities in reelin signaling and the relationship between reelin deficiency and principal neuroendocrine pathways are discussed.
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