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Noninvasive brachial-ankle pulse wave velocity in hypertensive patients with left ventricular hypertrophy

Kyoung-Ha Park1, Woo Jung Park, Min-Kyu Kim

  • 1Cardiovascular Division, Department of Internal Medicine, Hallym University Medical Center, Seoul, Korea. pkhmd@naver.com

American Journal of Hypertension
|December 17, 2009
PubMed

Insights

Elevated brachial-ankle pulse wave velocity (baPWV) is linked to higher left ventricular filling pressure (LVFP) in hypertensive patients with LV hypertrophy. This noninvasive measure shows promise for assessing LVFP in this population.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Vascular Physiology

Background:

  • Elevated left ventricular filling pressure (LVFP) is a key prognostic indicator in hypertension.
  • Left ventricular hypertrophy (LVH) is common in hypertensive patients.
  • Noninvasive assessment of LVFP is clinically valuable.

Purpose of the Study:

  • To investigate the association between noninvasive brachial-ankle pulse wave velocity (baPWV) and LVFP in hypertensive patients with LVH.
  • To determine if baPWV can serve as a surrogate marker for elevated LVFP.

Main Methods:

  • Enrolled hypertensive patients with LVH and preserved LV ejection fraction (LVEF > or = 55%).
  • Measured baPWV and Doppler echocardiographic parameters of LVFP.
  • Evaluated correlation with B-type natriuretic peptide (BNP).

Main Results:

  • Patients with elevated LVFP (E/Ea >15) had significantly higher baPWV compared to those with normal LVFP.
  • baPWV demonstrated a strong correlation with E/Ea (r=0.69, P<0.01), outperforming BNP (r=0.47, P<0.01).
  • Multivariate analysis confirmed baPWV as an independent predictor of elevated LVFP; ROC analysis showed good diagnostic performance (AUC=0.79).

Conclusions:

  • Elevated baPWV is significantly associated with increased LVFP in hypertensive patients with LVH and preserved systolic function.
  • baPWV is a reliable noninvasive marker for detecting elevated LVFP in this patient group.
  • These findings support the use of baPWV in the clinical assessment of hypertensive patients with LVH.
Abstract

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