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Related Experiment Video

Updated: Jun 17, 2026

Brain Imaging Investigation of the Impairing Effect of Emotion on Cognition

Brain Imaging Investigation of the Impairing Effect of Emotion on Cognition

Published on: February 1, 2012

Dysbindin-1 genotype effects on emotional working memory.

C Wolf¹, M C Jackson, C Kissling

¹Wolfson Centre for Cognitive and Clinical Neuroscience, School of Psychology, Bangor University, Bangor, UK.

Molecular Psychiatry

|December 17, 2009

Summary

This summary is machine-generated.

Genetic variations in dysbindin-1 (DTNBP1) impact working memory (WM) for emotional faces. Individuals with higher DTNBP1 expression showed enhanced WM capacity and increased brain activity in key regions, particularly for happy faces.

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Area of Science:

Neuroscience
Genetics
Cognitive Science

Background:

Dysbindin-1 (DTNBP1) is a synaptic protein implicated in schizophrenia.
Genetic variations in DTNBP1 are associated with its expression levels.
Understanding DTNBP1's role in cognition is crucial for psychiatric research.

Purpose of the Study:

To investigate the behavioral and neural effects of DTNBP1 genotype variations.
To examine the relationship between DTNBP1 expression and working memory (WM) for emotional stimuli.
To explore the impact of DTNBP1 on task-related brain activation.

Main Methods:

Combined functional neuroimaging (fMRI) with genetic analysis.
Utilized a working memory task involving emotional faces.
Compared participants based on DTNBP1 genotype related to protein expression levels.

Main Results:

Participants with higher DTNBP1 expression showed increased WM capacity for happy faces.
Elevated brain activity was observed in hippocampal, temporal, and frontal cortex areas.
Brain activation increases were emotion-specific and correlated with performance, especially for happy faces.

Conclusions:

DTNBP1 genetic variability influences emotion-specific working memory capacity.
DTNBP1 affects region-specific task-related brain activation in humans.
Findings link cellular/molecular mechanisms (DTNBP1, neurotransmission) to systems/behavioral outcomes in cognition.