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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Hepatitis01:25

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Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver.
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Viral Hepatitis I: Introduction01:28

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Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion...
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Cirrhosis I: Introduction01:23

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Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
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Intrasplenic Transplantation of Hepatocytes After Partial Hepatectomy in NOD.SCID Mice
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Hepatitis C and liver transplantation.

G Tsoulfas1, I Goulis, D Giakoustidis

  • 1Surgical Department of Transplantation, Aristotle University, Hippokratio General Hospital, Thessaloniki, Greece. tsoulfasg@msn.com

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Summary

Chronic hepatitis C often leads to cirrhosis, making liver transplantation common. Post-transplant reinfection is frequent, necessitating better understanding of hepatitis C and its treatments, including liver transplants.

Keywords:
hepatitis C virushepatocellular carcinomaorthotopic liver transplantation

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Area of Science:

  • Hepatology
  • Virology
  • Transplantation Medicine

Background:

  • Chronic hepatitis C is a primary cause of liver cirrhosis and the leading indication for liver transplantation globally.
  • Reinfection with hepatitis C virus (HCV) post-liver transplant is nearly universal.
  • HCV recurrence post-transplantation often follows an accelerated disease course.

Purpose of the Study:

  • To review the scope of chronic hepatitis C infection.
  • To discuss various treatment modalities for hepatitis C.
  • To emphasize the role and outcomes of orthotopic liver transplantation for hepatitis C-induced cirrhosis.

Main Methods:

  • Literature review of scientific publications on hepatitis C.
  • Analysis of epidemiological data regarding liver transplantation indications.
  • Synthesis of information on treatment strategies and post-transplant outcomes.

Main Results:

  • Cirrhosis from chronic hepatitis C is the primary reason for liver transplants in major regions.
  • Over 70% of liver transplant recipients develop recurrent chronic liver disease within 3 years.
  • The disease progression post-transplant is often more rapid than in non-transplant patients.

Conclusions:

  • Effective management of hepatitis C is crucial, especially in the context of liver transplantation.
  • Orthotopic liver transplantation is a significant treatment for end-stage liver disease due to hepatitis C.
  • Further research into understanding and mitigating HCV recurrence post-transplant is essential.