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A Mouse Model of Intestinal Partial Obstruction
Published on: March 5, 2018
Acute intestinal pseudo-obstruction (Ogilvie's syndrome)
1Department of Surgery, Eastern Virginia Medical School, Norfolk, Virginia, USA.
Clinics in Colon and Rectal Surgery
|December 17, 2009
Summary
Acute colonic pseudo-obstruction (ACPO), or Ogilvie's syndrome, causes massive colon swelling without blockage. While often manageable with conservative treatment, delayed recognition risks fatal perforation.
Area of Science:
- Gastroenterology
- Colorectal Surgery
- Internal Medicine
Background:
- Acute colonic pseudo-obstruction (ACPO), known as Ogilvie's syndrome, presents as significant colonic distension.
- This condition occurs without any mechanical blockage in the colon.
- It is frequently associated with underlying medical or surgical conditions.
Purpose of the Study:
- To review the pathophysiology of Ogilvie's syndrome.
- To examine the epidemiology of acute colonic pseudo-obstruction.
- To discuss current and potential treatment strategies for ACPO.
Main Methods:
- Literature review of pathophysiology.
- Epidemiological data analysis.
- Review of clinical management and treatment options.
Main Results:
- ACPO involves massive colonic distension due to autonomic dysfunction.
- Predisposing factors include major surgery, critical illness, and certain medications.
- Conservative management is often effective, but delayed diagnosis can lead to cecal perforation.
Conclusions:
- Ogilvie's syndrome requires prompt recognition and management.
- Conservative measures are the first line of treatment.
- Early intervention can prevent severe complications like perforation and reduce mortality.
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