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Related Concept Videos

Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...
Protein-Protein Interfaces02:04

Protein-Protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...
Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Protein Organization01:13

Protein Organization

Overview

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Updated: Jun 17, 2026

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
13:56

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions

Published on: July 18, 2013

Human cancer protein-protein interaction network: a structural perspective.

Gozde Kar1, Attila Gursoy, Ozlem Keskin

  • 1Center for Computational Biology and Bioinformatics and College of Engineering, Koc University, Rumeli Feneri Yolu, Sariyer Istanbul, Turkey.

Plos Computational Biology
|December 17, 2009
PubMed
Summary

Cancer-related proteins have distinct interface properties, often acting as multi-interface hubs. This understanding aids in identifying new cancer targets and understanding drug interactions.

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Area of Science:

  • Biochemistry
  • Bioinformatics
  • Systems Biology

Background:

  • Protein-protein interactions (PPIs) are crucial for cellular functions and biological processes.
  • Dysfunctional PPIs are implicated in various diseases, notably cancer.
  • Protein interfaces mediate these interactions, making their study vital for understanding disease mechanisms.

Purpose of the Study:

  • To develop a methodology integrating protein interfaces into cancer interaction networks (ciSPIN).
  • To analyze the properties of cancer-related protein interfaces and their network topology.
  • To identify potential biomarkers and therapeutic targets in cancer.

Main Methods:

  • Integration of known or predicted protein complexes into the human protein interaction network to form the cancer structural protein interface network (ciSPIN).
  • Analysis of topological properties and interface characteristics of cancer-related proteins within ciSPIN.
  • Classification of genes by phenotypes and comparison of interface properties between cancer and non-cancer proteins.

Main Results:

  • Cancer-related protein interfaces are generally smaller, more planar, more charged, and less hydrophobic than those of non-cancer proteins.
  • Interface properties can discriminate cancer-related proteins from non-cancer proteins with significant accuracy (e.g., 71% for breast cancer).
  • Cancer-related proteins predominantly function as multi-interface hubs (56%), indicating essentiality in the network (76%).

Conclusions:

  • Cancer-related protein interfaces exhibit unique biophysical properties suggesting specific interaction dynamics.
  • Multi-interface hubs are prevalent among cancer proteins and are critical network nodes.
  • These findings offer insights into cancer mechanisms and potential avenues for novel therapeutic strategies.