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The hepatocyte growth factor receptor (MET) gene is not associated with refractive error and ocular biometrics in a
M Schache1, C Y Chen, M Dirani
1Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia. mschache@unimelb.edu.au
Purpose:
The purpose of this study was to determine if genetic variants in the hepatocyte growth factor receptor (MET) gene are associated with refractive error and ocular biometric measures in a Caucasian cohort.
Methods:
A case-control association study using 818 Caucasian adults (37.2% male, 62.8% female; average age: 51.21+/-17.17 years) was undertaken. All individuals were genotyped for 16 tag single nucleotide polymorphisms (tSNPs) across the MET gene region. Myopia was defined as -0.5 DS or worse in both eyes and divided into high myopia (
Results:
No statistically significant genetic associations were detected for any of the 16 tSNPs with refractive error (myopia and hypermetropia) or ocular biometric measures.
Conclusions:
These data indicate there is likely no genetic association of the MET gene with myopia, axial length, anterior chamber depth, and corneal curvature in this cohort.
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