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Updated: Jun 17, 2026
08:58
Murine Kidney Transplant Technique
Published on: October 20, 2015
Multiple cavitating nodules in a renal transplant recipient
Sharla-Rae J Olsen1, Mohit Bhutani
1Department of Medicine, University of Alberta Hospital, Edmonton, Canada. sjo@ualberta.ca
Canadian Respiratory Journal
|December 17, 2009
Summary
Post-transplant lymphoproliferative disorder can present as multiple cavitating pulmonary nodules, a rare finding. This case highlights a unique radiographic presentation in a renal transplant recipient.
Area of Science:
- Oncology
- Transplantation Medicine
- Radiology
Background:
- Pulmonary nodules are frequent after solid organ transplantation, with diverse causes.
- Central cavitation in nodules often suggests an infectious etiology in transplant patients.
Observation:
- A 45-year-old female renal transplant recipient presented with constitutional symptoms and bilateral cavitating pulmonary nodules.
- Imaging revealed numerous randomly dispersed cavitating nodules in the lungs, alongside liver and spleen lesions.
Findings:
- A liver biopsy diagnosed an Epstein-Barr virus-negative diffuse large B-cell lymphoma.
- The patient received a chemotherapy regimen including cyclophosphamide, doxorubicin, vincristine, and prednisone/prednisolone.
Implications:
- This case describes a novel radiographic presentation of post-transplant lymphoproliferative disorder (PTLD).
- The findings expand the known spectrum of PTLD manifestations in solid organ transplant recipients.
- Early recognition of this unusual presentation is crucial for timely and effective treatment.
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