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Malaria

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...

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Related Experiment Video

Updated: Jun 17, 2026

Intravital Microscopy of the Spleen: Quantitative Analysis of Parasite Mobility and Blood Flow

Intravital Microscopy of the Spleen: Quantitative Analysis of Parasite Mobility and Blood Flow

Published on: January 14, 2012

Experimental splenectomies and malaria in mice.

Róbson Miguel de Araújo Negreiros¹, Fabiano Hiromichi Makimoto, Linda Luciana Oliveira Santana

¹Surgery Clinical Department, School of Medicine, UFAM, R. Afonso Pena 1053, Manaus, Amazonas, Brazil. negreirosrobson@hotmail.com

Acta Cirurgica Brasileira

|December 17, 2009

Summary

The spleen plays a crucial role in clearing Plasmodium berghei infected red blood cells in mice. Preserving spleen function is vital for managing malaria complications.

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Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites

Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites

Published on: May 18, 2016

Area of Science:

Immunology
Infectious Diseases
Parasitology

Background:

The spleen's role in malaria pathogenesis is not fully understood.
Splenic function is critical for clearing infected erythrocytes and modulating immune responses.

Purpose of the Study:

To investigate the spleen's importance in malaria infection using a murine model.
To compare parasitemia levels and immunoglobulin titers in mice with varying degrees of splenic function.

Main Methods:

Female mice were inoculated with Plasmodium berghei ANKA.
Parasitemia was assessed via Giemsa-stained blood smears on specific days.
Serum immunoglobulin (IgM, IgG) levels were quantified using Dot-ELISA.

Main Results:

Parasitemia increased gradually in all infected groups.
Mice with partial splenectomy showed higher parasitemia than non-splenectomized controls.
Asplenic mice exhibited significantly higher parasitemia compared to other groups.
Total serum IgM and IgG levels did not significantly change with splenic removal.

Conclusions:

Spleen-preserving surgical techniques are feasible and necessary in cases of splenic trauma.
The spleen is efficient in clearing Plasmodium berghei-infected red blood cells.
Maintaining splenic integrity is crucial for preventing severe malaria complications in mice.