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Updated: Jun 17, 2026
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Establishment of an Ex Vivo Lung Perfusion Rat Model for Translational Insights in Lung Transplantation
Published on: September 29, 2023
Ex vivo lung perfusion: initial Brazilian experience
Paulo Manuel Pêgo-Fernandes1, Israel Lopes de Medeiros, Alessandro Wasum Mariani
1Department of Thoracic Surgery, University of São Paulo School of Medicine, São Paulo, Brazil. paulopego@incor.usp.br
Summary
Lung transplantation is a standard treatment, but few donor lungs are usable. Ex vivo lung perfusion offers a new method to recondition rejected lungs for transplantation, potentially increasing donor lung availability.
Area of Science:
- Cardiovascular Medicine
- Thoracic Surgery
- Transplantation Immunology
Background:
- Lung transplantation is the standard treatment for end-stage lung disease.
- Less than 20% of available donor lungs are suitable for transplant.
- High mortality rates exist for lung transplant candidates due to donor lung scarcity.
Purpose of the Study:
- To describe the initial experience with ex vivo lung perfusion (EVLP).
- To evaluate EVLP as a method for reconditioning rejected donor lungs.
- To assess the potential of EVLP to increase the number of lung transplants.
Main Methods:
- Utilized a novel method for reconditioning human donor lungs developed in Sweden.
- Applied ex vivo lung perfusion (EVLP) to previously rejected lungs.
- Described the initial clinical experience and outcomes of EVLP.
Main Results:
- The study details the initial application of EVLP in a clinical setting.
- EVLP was used to recondition donor lungs that were initially unsuitable for transplant.
- The findings represent early experience with this lung reconditioning technique.
Conclusions:
- Ex vivo lung perfusion (EVLP) is a promising technique for lung reconditioning.
- EVLP may help overcome the shortage of donor lungs for transplantation.
- Further experience is needed to fully establish the role of EVLP in lung transplantation.
