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Updated: Jun 17, 2026

Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles (PPAs) and Related Biomaterials
08:55

Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles (PPAs) and Related Biomaterials

Published on: June 25, 2018

Potential anticancer application of polyamine oxidation products formed by amine oxidase: a new therapeutic approach

E Agostinelli1, G Tempera, N Viceconte

  • 1Department of Biochemical Sciences - SAPIENZA University of Rome and CNR, Biology and Molecular Pathology Institutes, Piazzale Aldo Moro 5, 00185, Rome, Italy. enzo.agostinelli@uniroma1.it

Amino Acids
|December 17, 2009
PubMed

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The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
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