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Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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Updated: Jun 17, 2026

Generation of Genetically Modified Mice through the Microinjection of Oocytes

Generation of Genetically Modified Mice through the Microinjection of Oocytes

Published on: June 15, 2017

Genetically engineered mouse models in drug discovery research.

Rosalba Sacca¹, Sandra J Engle, Wenning Qin

¹Genetically Modified Models Center of Emphasis, Pfizer Global Research and Development, Pfizer Inc., Groton, CT, USA.

Methods in Molecular Biology (Clifton, N.J.)

|December 17, 2009

Summary

This summary is machine-generated.

Genetically modified mouse models accelerate drug discovery by mimicking human diseases. Comprehensive phenotyping programs identify novel phenotypes and safety concerns, enhancing target validation for new therapeutics.

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Area of Science:

Biomedical Research
Pharmacology
Genetics

Background:

Genetically modified mouse models are crucial for drug discovery and target validation.
These models allow for the study of human diseases and conserved signaling pathways.
Existing technologies have limitations, including founder heterogeneity and unpredictable phenotypes.

Purpose of the Study:

To address limitations in genetically modified mouse models for drug discovery.
To develop a comprehensive phenotyping program for in-depth target knowledge.
To identify novel phenotypes and potential safety concerns associated with drug targets.

Main Methods:

Utilizing genetically modified mouse models (transgenic and knock-out).
Implementing a comprehensive phenotyping program to analyze animal models.
Exploring innovative technologies like RNA interference (RNAi) and humanized models.

Main Results:

Identification of novel phenotypes in genetically modified mice.
Detection of potential safety concerns related to specific drug targets.
Enhanced understanding of target genes and their roles in disease.

Conclusions:

Comprehensive phenotyping is essential for robust drug target validation.
Genetically modified mouse models, when thoroughly analyzed, are invaluable for drug discovery.
Ongoing exploration of new technologies will further refine preclinical research.