Related Experiment Video
Updated: Jun 17, 2026

Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models
Published on: March 29, 2019
Virological and cellular roles of the transcriptional coactivator LEDGF/p75
Manuel Llano1, James Morrison, Eric M Poeschla
1Biological Sciences Department, University of Texas, El Paso, TX 79968-0519, USA. mllano@utep.edu
Abstract:
The chromatin-associated cellular proteins LEDGF/p75 and LEDGF/p52 have been implicated in transcriptional regulation, cell survival and autoimmunity. LEDGF/p75 also appears to act as a chromatin-docking factor or receptor for HIV-1 and other lentiviruses and to play a role in leukemogenesis. For both the viral and cellular roles of this protein, a key feature is its ability to act as a molecular adaptor and tether proteins to the chromatin fiber. This chapter reviews the emerging roles of LEDGF/p75 and LEDGF/p52 in diverse cellular processes and disease states.
Related Concept Videos
Co-activators and Co-repressors
Co-activators and Co-repressors
Master Transcription Regulators
Master Transcription Regulators
General Transcription Factors
TGF - β Signaling Pathway

