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Malignancy-associated multicentric reticulohistiocytosis
Boutros El-Haddad1, Dalia Hammoud, Timothy Shaver
1Internal Medicine Department, Kansas University School of Medicine, Wichita, KS 67206, USA.
Rheumatology International
|December 17, 2009
Summary
Multicentric reticulohistiocytosis (MR), a rare systemic disease, can be linked to cancer. This case study shows successful treatment of MR with chemotherapy and steroids, followed by remission after lung cancer resection.
Area of Science:
- Rheumatology
- Oncology
- Dermatology
Background:
- Multicentric reticulohistiocytosis (MR) is a rare systemic disorder with unknown causes.
- A significant percentage of MR patients (up to 25%) present with associated malignancies.
- The interplay between MR and malignancy requires further investigation for optimal patient management.
Observation:
- A patient with MR initially responded well to methotrexate and prednisone.
- Prednisone tapering led to disease flare-ups, indicating persistent underlying pathology.
- Diagnostic workup identified an associated localized squamous cell carcinoma of the lung.
Findings:
- Surgical resection of the lung carcinoma resulted in complete remission of MR.
- Methotrexate and prednisone were successfully tapered and discontinued post-surgery.
- This suggests a potential paraneoplastic etiology for MR in this case.
Implications:
- Early detection and management of associated malignancies may be crucial for treating MR.
- Treatment strategies for MR should consider the potential link to underlying cancers.
- This case highlights the importance of a multidisciplinary approach in managing complex cases of MR.
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