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Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
Viral Recombination00:57

Viral Recombination

Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...

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Related Experiment Video

Updated: Jun 17, 2026

Real-time Imaging of Heterotypic Platelet-neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice
11:18

Real-time Imaging of Heterotypic Platelet-neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice

Published on: April 2, 2013

Platelets and viruses: an ambivalent relationship.

Claire Flaujac1, Siham Boukour, Elisabeth Cramer-Bordé

  • 1Service d'Hématologie et d'Immunologie, Hôpital Ambroise Paré, Boulogne-Billancourt, 92100 Paris, France. claire.flaujac@htd.aphp.fr

Cellular and Molecular Life Sciences : CMLS
|December 17, 2009
PubMed
Summary
This summary is machine-generated.

Platelets interact with viruses through various mechanisms, impacting viral infections and potentially leading to thrombocytopenia. Further research is needed to clarify platelet roles and ensure viral safety in blood transfusions.

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Area of Science:

  • Hematology
  • Virology
  • Immunology

Background:

  • Thrombocytopenia (low platelet count) is common in viral infections.
  • Viral interactions with platelets involve complex pathophysiological mechanisms.

Purpose of the Study:

  • To review the diverse pathways of platelet-virus interactions.
  • To highlight the role of platelets in viral pathogenesis and transfusion safety.

Main Methods:

  • Review of existing literature on platelet-virus interactions.
  • Analysis of mechanisms including receptor binding and internalization.

Main Results:

  • Viruses bind platelets via specific receptors, altering both entities.
  • Human Immunodeficiency Virus type 1 (HIV-1) can be internalized by platelets and megakaryocytes.
  • Platelet interactions can lead to virus destruction or facilitate viral clearance.

Conclusions:

  • Platelet roles in viral infections require further elucidation.
  • Ensuring viral safety in platelet transfusions remains a critical challenge.