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Updated: Jun 17, 2026

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
Published on: July 22, 2021
Nonunions around the knee joint
Daniel B Chan1, Devon M Jeffcoat, Dean G Lorich
1Orthopedic Trauma Service, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA.
Abstract:
Nonunions of the distal femur are relatively rare but can occur with or without previous surgery. Many surgical methods have been described for the treatment of these nonunions including external fixation, intramedullary nailing, arthroplasty, and fixed angle plating. While arthroplasty may have a limited role in the elderly patient with osteoporosis and severe communiution, most nonunions can be reliably treated with revision fixation using a fixed angled device, lag screws, and bone grafting as needed. Fixed-angle plating also has the advantage of stabilising a small distal segment where intramedullary nailing has proven to be less effective. Any surgical intervention must include restoration of the normal mechanical axis of the distal femur for a satisfactory clinical outcome. Proximal tibia nonunions are a similarly rare clinical entity due to the excellent blood supply in the metaphysis. Extra-articular proximal tibial nonunions are often due to malreduction during the index surgery resulting in poor bone contact and biomechanical stability. Soft tissue forces and improper use of intramedullary implants often predispose these fractures to malalignment. Revision surgery consisting of deformity correction and at least a lateral tension band plate with lag screws has led to predictable union and good clinical results. Tibial plateau nonunions are exceedingly uncommon but are difficult to treat because of small, often devascularised fragments, post-surgical scarring, and osteopenia. Revision surgery with meticulous soft tissue handling to restore the articular surface and mechanical axis with repair of meniscal pathology gives the patient the best chance of recovering knee function.
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