Related Experiment Video
Updated: Jun 17, 2026

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
Published on: September 13, 2024
Histamine intolerance: a metabolic disease?
1Department of Visceral, Transplant and Thoracic Surgery, Medical University Innsbruck, Innsbruck, Austria. hubert.schwelberger@i-med.ac.at
Objective:
To evaluate the evidence regarding the disease concept of histamine intolerance as a state of inadequate histamine inactivation.
Methods:
Keyword-based systematic screening of the scientific literature and of public websites focusing on diagnostic and therapeutic procedures.
Results:
Histamine intolerance is commonly diagnosed based solely on subjective reporting of symptoms instead of following systematic diagnostic procedures based on objective laboratory and physical parameters. The only effective long-term therapy is avoidance of histamine-containing food.
Conclusions:
The concept of histamine intolerance as a metabolic disease is in need of more experimental and clinical evidence and affected patients will benefit from a clear, evidence-based diagnostic and therapeutic regime.
Related Concept Videos
Other Disorders of Digestive System
Inborn Errors of Metabolism
Gastritis II: Pathophysiology
Overview of Carbohydrate Metabolism
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Gastritis-II: Pathophysiology
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Lysosomal Hydrolases
