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Updated: Jun 17, 2026
Surgical Model for Single-Staged Tissue-Engineered Urothelial Tubes in Minipigs
Published on: July 5, 2024
The use of seromuscular tapered ileal tube in ureteral replacement: an experimental model
Mahmoud Ezzat Ibrahim1, Mohamed M Ezzat, Wail M Ezzat
1mezzat2005@gawab.com
Purpose:
To assess the capability of urothelium to proliferate, creep and line the inner surface of the interposed seromuscular tapered ileal tube.
Materials And Methods:
Under general anesthesia, 15 female dogs underwent resection of 5 cm of the mid ureter and replaced with tapered seromuscular ileal tube stented for 6 weeks. The animals were sacrificed, and cross section of the ileal ureters were examined histologically for the lining cells.
Results:
Multilayer of transitional epithelium was seen covering all the inner surface of the interposed seromuscular tube at the end of 6 weeks. Excessive inflammatory cell infiltration was a prominent finding in the submucosal layer.
Conclusion:
Transitional epithelium has the capability to proliferate, grow and cover the inner surface of the interposed seromuscular ileal tube. Urothelium lining avoid the metabolic complications of the intestinal mucosa.
