Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Micelles

Micelles

Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...

Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules

Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules

Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...

Modified-Release Drug Delivery Systems: Rate-Programmed I

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...

Dose-Response Relationship: Potency and Efficacy

Dose-Response Relationship: Potency and Efficacy

The potency of a drug is the measure of its ability to produce a biological response and can be compared by looking at the half-maximum effective concentration or EC50 values of different drugs. A lower EC50 value indicates higher potency of the drug. In the dose–response curve of two antihypertensive drugs, candesartan and irbesartan, a significant difference is observed in their EC50 values. A lower EC50 value for candesartan indicates that it is more potent than irbesartan, as it produces...

Bioavailability Enhancement: Drug Solubility Enhancement

Bioavailability Enhancement: Drug Solubility Enhancement

Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Topical Delivery of Carvedilol Loaded Nano-Transfersomes for Skin Cancer Chemoprevention.

Pharmaceutics·2020

Same author

Skin delivery of resveratrol encapsulated lipidic formulation for melanoma chemoprevention.

Journal of microencapsulation·2019

Same author

An integrated dataset on current adoption practices, readiness and willingness to use m-commerce amongst women fish vendors in Karnataka state, India.

Data in brief·2019

Same author

Design, analysis and performance evaluation of a hand gesture platform for navigation.

Technology and health care : official journal of the European Society for Engineering and Medicine·2019

Same author

In Situ Salification in Polar Solvents: a Paradigm for Enabling Drug Delivery of Weakly Ionic Drugs as Amorphous Solid Dispersion.

AAPS PharmSciTech·2017

Same author

Comparative evaluation of proliposomes and self micro-emulsifying drug delivery system for improved oral bioavailability of nisoldipine.

International journal of pharmaceutics·2016

Search research articles

Related Experiment Video

Updated: Jun 17, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

Solid self-microemulsifying formulation for candesartan cilexetil.

Vijaykumar Nekkanti¹, Pradeep Karatgi, Raghavendra Prabhu

¹NCE Product Development, Integrated Product Development Organization, Dr Reddy's Laboratories Limited, Innovation Plaza, Bachupally, Qutubullapur, Hyderabad 500072, India.

AAPS Pharmscitech

|December 17, 2009

Summary

This summary is machine-generated.

Developing self-microemulsifying drug delivery systems (SMEDDS) for candesartan cilexetil improved its solubility and dissolution. Solid SMEDDS formulations demonstrated enhanced drug release compared to commercial tablets, showing potential for increased bioavailability.

More Related Videos

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

Related Experiment Videos

Last Updated: Jun 17, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

Area of Science:

Pharmaceutical Sciences
Drug Delivery Systems
Physical Pharmacy

Background:

Poorly water-soluble drugs like candesartan cilexetil present bioavailability challenges.
Developing effective drug delivery systems is crucial for enhancing therapeutic efficacy.

Purpose of the Study:

To develop and characterize self-microemulsifying drug delivery systems (SMEDDS) of candesartan cilexetil.
To evaluate the potential of SMEDDS for improving drug solubility, dissolution, and bioavailability.
To convert liquid SMEDDS into a solid dosage form for capsule filling.

Main Methods:

Solubility studies of candesartan cilexetil in various non-aqueous carriers.
Construction of pseudoternary phase diagrams to identify self-microemulsification regions.
Formulation and characterization of liquid SMEDDS, including droplet size and zeta potential.
Conversion of liquid SMEDDS to solid intermediates by adsorption onto a carrier.
Dissolution testing of solid SMEDDS capsules compared to liquid and commercial formulations.

Main Results:

Optimized SMEDDS formulations were successfully prepared.
The conversion of liquid SMEDDS to solid intermediates did not affect self-emulsifying properties.
Solid SMEDDS formulations exhibited comparable dissolution rates to liquid SMEDDS.
Drug dissolution from solid SMEDDS was significantly higher than from the commercial tablet.

Conclusions:

SMEDDS are a viable approach for enhancing the solubility and dissolution of candesartan cilexetil.
The conversion to a solid form maintains the self-emulsifying characteristics and improves drug release.
This approach holds promise for improving the oral bioavailability of poorly soluble drugs.